In 1818 he was inducted into the Greek patriotic organization Filiki Eteria and, in 1819, he was appointed Derven-Agas (guard of the mountains passes) in eastern Central Greece. Odysseus Androutsos took part in the battles of Verati, Argyrokastro and Gardiki, and Ali Pasha titled him as the chieftain of Livadia. In 1820, when Ali Pasha clashed with the Porte, he left Livadia, after first inducting Athanasios Diakos into Filiki Eteria. At the beginning of 1821, he met with Karaiskakis, Georgios Varnakiotis, Zoggas, Makris, Kyriakoulis Mavromichalis and other chieftains of the Peloponnese and Central Greece. It was decided to assign the Eastern Central Greece uprising control to Androutsos and Panourgias. The decisions of the meeting were immediately implemented, as Androutsos, along with a group of his men, attacked the enemies at the bridge of Tatarna. The enemies, led by Derven-Aga Hassan Bay Gekka, were accompanying a large cash-in-transit.
The culmination of the battles of Androutsos was the heroic Battle of Gravia Inn (May 8, 1821). In this battle, Androutsos’ strategic ingenuity triumphed. Thus, he was rightfully given the tittle of Commander in Chief of Boeotia.
In the spring of 1822, he was accused by Ioannis Kolettis of collaborating with the enemy, resulting in his dismissal as commander. On August 27, 1822, the Supreme Court entrusted him with the Administration of Athens and he entered the Acropolis, accompanied by Ioannis Makriyannis, Ioannis Gkouras, Ioannis Mamouris, Katsikogiannis and three hundred armed rebels. Androutsos continued his war actions against the Turks until 1824.
Androutsos was eventually wrongly accused of collaboration with the Turks. He was persecuted and lost his power and authority during the civil conflicts that followed. On June 5, 1825, Odysseus Androutsos, imprisoned on false charges in the Acropolis, was tortured and killed.